Effects of a Perindopril-Based Blood Pressure–Lowering Regimen on the Risk of Recurrent Stroke According to Stroke Subtype and Medical History
作者： N. Chapman , R. Huxley , C. Anderson , M.G. Bousser , J. Chalmers
DOI: 10.1161/01.STR.0000106480.76217.6F
关键词: Stroke 、 Cardiology 、 Indapamide 、 Intracerebral hemorrhage 、 Internal medicine 、 Relative risk reduction 、 Relative risk 、 Contraindication 、 Perindopril 、 Surgery 、 Medicine 、 Risk factor
摘要: Background and Purpose— The Perindopril Protection Against Recurrent Stroke Study (PROGRESS) showed that blood pressure lowering reduced stroke risk in patients with a history of cerebrovascular events. Here, we report the consistency treatment effects across different subtypes among major clinical subgroups. Methods— PROGRESS was randomized, double-blind trial 6105 people prior Participants were assigned to active (perindopril for all participants indapamide those neither an indication nor contraindication diuretic) or matching placebo(s). Results— During mean 3.9 years follow-up, absolute rates ischemic from 10% 8% (relative reduction [RRR], 24%; 95% confidence interval [CI], 10 35) intracerebral hemorrhage 2% 1% (RRR, 50%; CI, 26 67). relative any during follow-up by 26% (95% CI...
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A. Rodgers, S. MacMahon, G. Gamble, J. Slattery, P. Sandercock, C. Warlow, Blood pressure and risk of stroke in patients with cerebrovascular disease BMJ. ,vol. 313, pp. 147- 147 ,(1996) , 10.1136/BMJ.313.7050.147
Lennart Hansson, Blood pressure lowering for the secondary prevention of stroke: rationale and design for PROGRESS J Hypertens suppl 2. ,vol. 14, pp. 41- ,(1996)
Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6105 individuals with previous stroke or transient ischaemic attack The Lancet. ,vol. 358, pp. 1033- 1041 ,(2001) , 10.1016/S0140-6736(01)06178-5
B.H.R. Wolffenbuttel, Hope Hope Study Investigators, Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy The Lancet. ,vol. 22, pp. 253- 259 ,(2000)
JohnM. Cruickshank, JeffreyM. Thorp, F.James Zacharias, BENEFITS AND POTENTIAL HARM OF LOWERING HIGH BLOOD PRESSURE The Lancet. ,vol. 329, pp. 581- 584 ,(1987) , 10.1016/S0140-6736(87)90231-5
Graeme J Hankey, Charles P Warlow, Treatment and secondary prevention of stroke: evidence, costs, and effects on individuals and populations* The Lancet. ,vol. 354, pp. 1457- 1463 ,(1999) , 10.1016/S0140-6736(99)04407-4
Ruth Bonita, Epidemiology of stroke The Lancet. ,vol. 339, pp. 342- 344 ,(1992) , 10.1016/0140-6736(92)91658-U
K Irie, T Yamaguchi, K Minematsu, T Omae, The J-curve phenomenon in stroke recurrence. Stroke. ,vol. 24, pp. 1844- 1849 ,(1993) , 10.1161/01.STR.24.12.1844
R Collins, S MacMahon, Blood pressure, antihypertensive drug treatment and the risks of stroke and of coronary heart disease British Medical Bulletin. ,vol. 50, pp. 272- 298 ,(1994) , 10.1093/OXFORDJOURNALS.BMB.A072892
Jan A Staessen, Robert Fagard, Lutgarde Thijs, Hilde Celis, Guramy G Arabidze, Willem H Birkenhäger, Christopher J Bulpitt, Peter W de Leeuw, Colin T Dollery, Astrid E Fletcher, Françoise Forette, Gastone Leonetti, Choudomir Nachev, Eoin T O' Brien, Joseph Rosenfeld, José L Rodicio, Jaakko Tuomilehto, Alberto Zanchetti, Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension * The Lancet. ,vol. 350, pp. 757- 764 ,(1997) , 10.1016/S0140-6736(97)05381-6