Promotion of calcification by imidazole and its suppression by diltiazem in the growth cartilage of rats with HEBP induced rickets

摘要: The object of our experiments was to determine the effect imidazole on growth cartilage rats with HEBP induced rickets. When (1-hydroxyethylidene-1, 1-bisphophonic acid) given young in large doses over a short period, rickets consistently produced. We found that had calcification promoting action plate where there been an increase thickness due inhibition calcification. In attempt clarify mechanism accelerated imidazole, effects diltiazem, calcium antagonist, were observed; it suppress If diltiazem inhibits entry ions into cells cartilage, as does smooth muscle and myocardial cells, then results indicate intracellular concentrations may play important role imidazole.