Regulation of HIV replication in monocytes by interferon.

摘要: The hallmark of human immunodeficiency virus (HIV) infection is the progressive loss CD4+ T-cells over a prolonged interval. In infected individual, two types cells are by HIV: and tissue macrophages. Levels HIV in blood tissues dependent upon change with stage infection. Acute infection, usually lasting weeks to months after initial exposure virus, characterized substantial viremia which actively replicates within leukocytes high titers free found plasma (more than 10 000 infectious virions/ml blood) (Clark et al. 1991; Daar 1991). chronic subclinical phase notable for low levels virus-infected (less 100 (Ho 1989). major reservoirs at frequency about 0.1 1% (Schnittman HIV-infected have on average only one proviral DNA copy integrated into genomic DNA. Less 0.1% these transcriptionally active any given time (Harper 1986; Simmonds 1990). During that express mRNA presumably produce 0.01% Clarke 1990; disease when very few producing blood, it likely provide most replicating maintains during long latent interval 8 12 years (Lifson 1988).