Echinococcus granulosus glycoconjugates induce peritoneal B cell differentiation into antibody-secreting cells and cytokine production.
作者： G. MOURGLIA-ETTLIN , M. C. AMEZCUA-VESELY , R. FRAGA , A. BAZ , M. C. MERINO
DOI: 10.1111/J.1365-3024.2011.01326.X
关键词: Immunology 、 Immune system 、 B-1 cell 、 Cytokine 、 Antigen 、 Cellular differentiation 、 Biology 、 Antibody 、 Echinococcus granulosus 、 B cell
摘要: Helminth parasite infections are associated with predominant Th2-type cytokine responses, and glycoconjugates have been recognized as partially responsible for such immune bias. It has proved that Echinococcus granulosus evokes a pattern characterized by high production of IL-4, IL-5, IL-6 IL-10, no or mild IFN-γ levels in animal models patients cystic echinococcosis, respectively. Here, we show E4(+) (a glycoconjugate-enriched fraction from E. protoscolex) stimulated the secretion concentration IL-6, followed IL-10 TNF-α normal peritoneal B cells. We determined bound to surface cells induced their activation and, also, triggered differentiation into IgM-, IgG2b- IgG3-secreting T-independent way. Interestingly, IgM released -stimulated mice protoscolex antigens. Results showed that, after encounter antigens protoscolex, source cytokines polyclonal antibodies, some which recognize antigens, suggesting can condition outcome infection.
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