CD8+/CD161++ mucosal-associated invariant T-cell levels in the colon are restored on lsong-term antiretroviral therapy and correlate with CD8+ T-cell immune activation
作者： Louise Greathead , Rebecca Metcalf , Brian Gazzard , Frances Gotch , Alan Steel
DOI: 10.1097/QAD.0000000000000351
关键词: CD8 、 Immune activation 、 Immunology 、 Cytotoxic T cell 、 Cell 、 Antiretroviral therapy 、 Mucosal associated invariant T cell 、 MAIT Cells 、 Medicine 、 Pathogenesis
摘要: Mucosal-associated invariant T (MAIT) cells are tissue-homing recently implicated in HIV pathogenesis. We found that the proportion of MAIT cell blood and colon HIV+ patients reduced untreated infection. Antiretroviral therapy restored colonic but not percentages. observed a negative correlation between T-cell activation suggest mucosal depletion may contribute to systemic immune
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