A novel 4-kb interleukin-13 receptor α mRNA expressed in human B, T, and endothelial cells encoding an alternate type-II interleukin-4/ interleukin-13 receptor

摘要: A 4 kb human interleukin-13 receptor (IL-13R) chain cDNA was cloned from a B cell library using expressed sequence tags homologous to mouse IL-13R as probes. The deduced protein shows significant level of identity with the IL-5R and identified recently by expression cloning. cytoplasmic region is very highly conserved between homologs contains consensus binding motif for signal transducer activator transcription. encodes IL-13 when alone which participates in complex both IL-4 conjunction IL-4R alpha chain. Transcripts this could be detected most tissues organs studied T, B, endothelial cells, basophilic, immature mast cell, monocytic lines. pattern different other molecule, correlates sites where signaling known occur. This novel therefore likely implicated reactions involved IgE responses, T helper 2 differentiation, adhesion leukocytes endothelium, pathological phenomena such allergy, atopy, asthma.