An Equivalence Trial Comparing Labetalol and Diltiazem in Controlling Emergence Hypertension after Supratentorial Tumor Surgery.

摘要: Background : Hypertension and tachycardia during emergence from anesthesia for craniotomy could increase risks of cerebral complications. Several anesthetic, sedative, antihypertensive drugs have been suggested that may be successful at suppressing these unwanted hemodynamic consequences. Objective To study the equivalent efficacy side effects two drugs, diltiazem labetalol. Material Method A block randomized control trial was performed in 184 patients who developed hypertensive response after supratentorial tumor removal. Systolic blood pressure (SBP) each patient suppressed by 2.5 mg repeated with fix dosage every to three minutes maintain SBP lower than 140 mmHg a cumulative dose within 20 mg. Data regarding demographic, rate controlling hypertension, drug dosage, incidence were analyzed. Results The success treatment labetalol (87.1% 80.2% respectively) [p = 0.003, 95% CI 6.88 (-2.06 15.8)]. There no statistical significant difference on used or effect (hypotension, bradycardia, heart block, bronchospasm). Median (minimum-maximum) 10 (2.5-20 mg) respectively. expense 1/6 diltiazem. Conclusion Labetalol has Both low median giving side-effects. is good alternative post-craniotomy. Keywords Labetalol, Diltiazem, Emergence Craniotomy