Hydrophobic Silica Nanoparticles Induce Gel Phases in Phospholipid Monolayers

摘要: Silica nanoparticles (SiNP) can be incorporated in phospholipid layers to form hybrid organic–inorganic bidimensional mesostructures. Controlling the dynamics these mesostructures paves way high-performance drug-delivery systems. Depending on different hydrophobicity/hydrophilicity of SiNP, recent X-ray reflectivity experiments have demonstrated opposite structural effects. While are reasonably well understood, less is known about effects dynamics, which turn determine molecular diffusivity and possibility drug release. In this work we characterize a mixed Langmuir layer made hydrophobic SiNP. We combine photon correlation spectroscopy epifluorescence discrete Fourier microscopy cover more than 2 decades Q-range (0.3–80 μm–1). obtain evidence for onset an arrested state characterized by intermittent stress-relaxation rearrangement events, corresponding gel dominated attractive interactions. co...