Antibacterial phloroglucinols derivatives from the leaves of Mallotus oppositifolius (Geisler) Müll. Arg. (Euphorbiaceae).
作者： Yvan Anderson Ngandjui Tchangoue , Joseph Tchamgoue , Paul Keilah Lunga , Janosch Knepper , Ramona Paltinean
DOI: 10.1016/J.FITOTE.2020.104527
关键词: Mallotus oppositifolius 、 Mallotojaponin 、 Minimum inhibitory concentration 、 Euphorbiaceae 、 Stereochemistry 、 Chemistry
摘要: Abstract From the ethno-medicinally used leaves of Mallotus oppositifolius, four acylphloroglucinol derivatives, namely Acronyculatin S U (1–3) and Mallotojaponin D (4) were isolated along with seven known compounds (5–11). Structures elucidated by comprehensive spectroscopic analyses HRMS data. Absolute configurations assigned careful comparison their specific optical rotation those closely related compounds. Compounds 1, 2, 6 11 demonstrated inhibitory activity against bacterial strains E. coli, S. aureus, typhi, P. aeruginosa minimum concentration (MIC) values ranging from 3.125 to 50 μg/ml.
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