Acquiring photoacoustic signature of hematocrit variation from plexus layer of in-silico human skin phantom.

摘要: Optical penetration inside human skin is constrained by the wavelength dependent scattering and absorption losses tissue microstructure chromophores. This computational study investigates whether signature of hematocrit variation from plexus i.e., first layer having very small blood volume percentage distributed in capillary vessels, retained detected photoacoustic response. Thein-silicoskin phantom irradiated a light source equivalent to footprint low power (below 5 W) continuous wave LASER diode. As fluence can be compensated exploiting strong targeted chromophores (hemoglobin molecules), an irradiation 405 nm has been used generate detectable pressure vessels plexus. energy deposition modelled using Monte Carlo technique computed k-wave. It found that with increase 10% 50%, amplitude monotonically increases gets almost doubled. The increment about 30% range physiological interest (from 50%).The follows quadratic relationship for entire range. further validated against minimum (800 Pa). numerical model expected important basis realize idea cost footprintin-vivophotoacoustic measurement device.