作者: Efstratios S Patsouris , Panagiota G Tsioli , Constantinos Giaginis , Stamatios E Theocharis
DOI: 10.14670/HH-28.971
关键词: Pathology 、 Cancer research 、 Point mutation 、 Biology 、 Sarcoma 、 Mutation 、 DNA repair 、 Soft tissue sarcoma 、 Gene 、 Rhabdomyosarcoma 、 DNA damage
摘要: Rhabdomyosarcoma (RMS) represents the most common soft tissue sarcoma in children and adolescent population. There are two major histological subtypes, embryonal (ERMS) alveolar (ARMS), differing cytogenetic morphological features. RMS pathogenesis remains controversial several cellular mechanisms pathways have been implicated. Application of intense chemo- radio-therapy improves survival rates for patients, but significant efficacy has not proved as DNA damage induced-resistance frequently occurs. The present review is aimed at summarizing current evidence on repair systems, implications development, focusing gene expression alterations point mutations genes encoding enzymes. Understanding systems involvement could diversify patients provide novel individualized therapeutic targets.