PRIMA subretinal wireless photovoltaic microchip implantation in non-human primate and feline models

摘要: Author(s): Muqit, Mahiul MK; Hubschman, Jean Pierre; Picaud, Serge; McCreery, Douglas B; van Meurs, Jan C; Hornig, Ralf; Buc, Guillaume; Deterre, Martin; Nouvel-Jaillard, Celine; Bouillet, Elodie; Fovet, Claire-Maelle; Hantraye, Philippe; Sahel, Jose; Martel, Joseph N; Le Mer, Yannick | Abstract: PURPOSE:To evaluate the surgical technique for subretinal implantation of two sizes PRIMA photovoltaic wireless microchip in animal models, and refine these procedures human trials. METHODS:Cats Macaca fascicularis primates with healthy retina underwent vitrectomy surgery were implanted at macula/central retina. The 1.5mm chip was initially studied feline eyes. implant (2mm,1.5mm sizes) arrays primates. Feasibility evaluated a newly-developed technique, complications adverse events recorded. RESULTS:The placed central 11 eyes, duration 43-106 days. correctly positioned into macula primate follow-up periods minimum 6 weeks (n = 11), 2 years 2), one eye 3 years. One multi-chip using chips. 2mm delivered to 4 Optical coherence tomography confirmed correct placement space all 26 Intraoperative eyes included retinal tear, macular hole, detachment, vitreous hemorrhage that resolved spontaneously. Postoperatively, there no case significant ocular inflammation group. CONCLUSIONS:We report low rate device-related complications. vivo has been developed refined use ongoing