Effects of Lactobacillus Plantarum and Lactobacillus Helveticus on Renal Insulin Signaling, Inflammatory Markers, and Glucose Transporters in High-Fructose-Fed Rats.

摘要: Background and Objectives: The excess consumption of fructose in the diet may cause metabolic syndrome, which is associated with an increased risk kidney disease. There limited data on probiotic treatment high-fructose-induced syndrome. present study aims to investigate whether supplementation Lactobacillus plantarum (L. plantarum) helveticus helveticus) could provide improving effect renal insulin signaling effectors, inflammatory parameters, glucose transporters fructose-fed rats. Materials Methods: model syndrome male Wistar rats was produced by fructose, given as 20% solution drinking water for 15 weeks. L. supplementations were gastric gavage from 10 weeks age. Results: High-fructose reduced protein expressions receptor substrate (IRS)-1, kinase B (AKT), endothelial nitric oxide synthase (eNOS), improved partially supplementations. Dietary fructose-induced elevations tissue levels tumor necrosis factor α (TNF-α), interleukin (IL)-1β, IL-6, IL-10, well expression IL-6 mRNA, attenuated, especially treated sodium-glucose cotransporter-2 (SGLT2), but not that transporter type-5 (GLUT5), suppressed plantarum. Conclusion: Suppression pathway together induction markers upregulation SGLT2 supplementation. These findings offer a new approach management dysregulation induced dietary high-fructose.