Adoptive cellular therapy of cancer: exploring innate and adaptive cellular crosstalk to improve anti-tumor efficacy.
作者： Kyle K Payne , Harry D Bear , Masoud H Manjili
DOI: 10.2217/FON.14.97
关键词: Chimeric antigen receptor 、 Lymphokine 、 Tumor microenvironment 、 Immune system 、 Innate immune system 、 Cell biology 、 Innate lymphoid cell 、 Antigen 、 Acquired immune system 、 Neuroscience 、 Biology
摘要: The mammalian immune system has evolved to produce multi-tiered responses consisting of both innate and adaptive cells collaborating elicit a functional response pathogen or neoplasm. Immune possess shared ancestry, suggestive degree coevolution that resulted in optimal functionality as an orchestrated highly collaborative unit. Therefore, the development therapeutic modalities harness should consider crosstalk between systems order most effective response. In this review, authors will discuss success achieved using adoptive cellular therapy treatment cancer, recent trends focus on purified T cells, with genetically modified T-cell receptors express chimeric antigen receptors, well use unfractionated cell reprogramming achieve upon infusion for therapy.
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