Quality of life assessment in Korean patients with pemphigus

摘要: Background: Measuring the quality of life (QOL) is important in evaluation nonclinical aspects diseases, for discovery functional and psychological limitations, choosing treatment initial phase disease. Pemphigus a potentially fatal autoimmune bullous disease caused by autoantibodies against desmogleins (cadherin family proteins desmosomes). Thus far, there has been no published study on QOL Korean patients with pemphigus. Objective: To impact pemphigus large number patients. Methods: Sixty-six enrolled at Gangnam Severance Hospital from March 2012 to 2013 were assessed using Dermatology Life Quality Index (DLQI), anxiety depression General Health Questionnaire (GHQ). Spearman’s rank-order correlation, t-test, ANOVA used identify relations between DLQI score other clinical variables. Results: vulgaris foliaceus significantly reduced The average all was 10.18. mean 13.45 active state 5.15 remission state. highly correlated severity, titer anti-desmoglein 1 enzyme-linked immunosorbent assay, corticosteroid dose. However, not affected sex, age, subtype pemphigus, duration disease, or comorbidities. Forty-two percent showed positive result GHQ, reflecting probable minor psychiatric nonpsychotic conditions, GHQ positively score. Conclusion: impairs correlates severity. Therefore, considerable attention should be paid patients’ states as well status. (Ann Dermatol 27(5) 492∼498, 2015)