Prognostic value of preoperative albumin to globulin ratio in patients treated with salvage radical prostatectomy for radiation recurrent prostate cancer.

摘要: Background Serum albumin-to-globulin ratio (AGR) has been shown to be associated with poor prognosis in different malignancies. In this study we aimed evaluate the predictive value of preoperative AGR for oncological outcomes patients radiation recurrent prostate cancer (PCa) treated salvage radical prostatectomy (SRP). Methods A retrospective review 214 consecutive radiation-recurrent PCa who underwent SRP at five referral centers. Levels albumin and globulin were obtained before used calculate level. The optimal cut off was 1.4. Univariable multivariable Cox regression analyses performed. Results Overall 89 (41.6%) had a low AGR. Low serum biochemical recurrence (BCR) univariable analysis (HR 1.60, 95%CI 1.06-2.43, P=0.026). When adjusted effects established postoperative clinicopathologic confounders models, association did not retain its statistical significance. Moreover, metastasis free survival (P= 0.21), overall 0.91) or specific (P=0.61). Conclusions undergoing SRP, risk BCR only analysis. There no outcomes. Further studies are needed biomarker setting primary identify most likely benefit from local therapy.