Simultaneous determination of residual veterinary drugs in bovine, porcine, and chicken muscle using liquid chromatography coupled with electrospray ionization tandem mass spectrometry.

摘要: A simple and rapid method using liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC/MS/MS) for the simultaneous determination of 130 veterinary drugs their metabolites in bovine, porcine, chicken muscle was developed. The (1 to 10 ng/g, muscle) were extracted from or muscles acetonitrile-methanol (95:5, v/v), extracts delipidated n-hexane saturated acetonitrile. evaporated, dissolved methanol, analyzed by gradient elution on a C18 column, determined spectrometry. detection limits ranged 0.03 3 ng/g. quantitation 0.1 One hundred eleven, 122, 123 respectively showed recoveries between 70 110%.