Central orexin facilitates gastric relaxation and contractility in rats
作者： Motoi Kobashi , Yuichi Furudono , Ryuji Matsuo , Takashi Yamamoto
DOI: 10.1016/S0304-3940(02)00958-8
关键词: Endocrinology 、 Orexin 、 Motility 、 Distal stomach 、 Contractility 、 Stomach 、 Neuropeptide 、 Internal medicine 、 Relaxation (psychology) 、 Biology 、 Gastric motility
摘要: The effects of the intracisternal administration synthetic orexin-A (3 nmol) on gastric motility were examined in rats. orexin but not a vehicle induced relaxation proximal stomach lasting for more than 30 min. Phasic contractions distal facilitated response to vehicle. Facilitation was observed animals which underwent sectioning bilateral vagi at subdiaphragmatic level. Relaxation vagotomized magnitude significantly smaller that intact animals. These results suggest central facilitates and via vagi.
elsevier.com
sci-hub.se 参考文章(19)
F.E. Bauer, A. Zintel, M.J. Kenny, D. Calder, M.A. Ghatei, S.R. Bloom, Inhibitory effect of galanin on postprandial gastrointestinal motility and gut hormone release in humans. Gastroenterology. ,vol. 97, pp. 260- 264 ,(1989) , 10.1016/0016-5085(89)90059-0
Motoi Kobashi, Masatoshi Mizutani, Ryuji Matsuo, Water stimulation of the posterior oral cavity induces inhibition of gastric motility. American Journal of Physiology-regulatory Integrative and Comparative Physiology. ,vol. 279, ,(2000) , 10.1152/AJPREGU.2000.279.3.R778
T.A. Harrison, C.-T. Chen, N.J. Dun, J.-K. Chang, Hypothalamic orexin A-immunoreactive neurons project to the rat dorsal medulla Neuroscience Letters. ,vol. 273, pp. 17- 20 ,(1999) , 10.1016/S0304-3940(99)00611-4
Jacob N. Marcus, Carl J. Aschkenasi, Charlotte E. Lee, Richard M. Chemelli, Clifford B. Saper, Masashi Yanagisawa, Joel K. Elmquist, Differential expression of orexin receptors 1 and 2 in the rat brain. The Journal of Comparative Neurology. ,vol. 435, pp. 6- 25 ,(2001) , 10.1002/CNE.1190
Leonard R. Johnson, Physiology of the Gastrointestinal Tract ,(1994)
Muhtashan S Mondal, Masamitsu Nakazato, Shigeru Matsukura, Orexins (hypocretins): novel hypothalamic peptides with divergent functions. Biochemistry and Cell Biology. ,vol. 78, pp. 299- 305 ,(2000) , 10.1139/O00-022
Takeshi Sakurai, Akira Amemiya, Makoto Ishii, Ichiyo Matsuzaki, Richard M Chemelli, Hirokazu Tanaka, S.Clay Williams, James A Richardson, Gerald P Kozlowski, Shelagh Wilson, Jonathan R.S Arch, Robin E Buckingham, Andrea C Haynes, Steven A Carr, Roland S Annan, Dean E McNulty, Wu-Schyong Liu, Jonathan A Terrett, Nabil A Elshourbagy, Derk J Bergsma, Masashi Yanagisawa, Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior Cell. ,vol. 92, pp. 573- 585 ,(1998) , 10.1016/S0092-8674(00)80949-6
Nobuhiko Takahashi, Toshikatsu Okumura, Hiroto Yamada, Yutaka Kohgo, Stimulation of Gastric Acid Secretion by Centrally Administered Orexin-A in Conscious Rats Biochemical and Biophysical Research Communications. ,vol. 254, pp. 623- 627 ,(1999) , 10.1006/BBRC.1998.9994
Zbigniew K. Krowicki, Hans R. Berthoud, Melissa A. Burmeister, Pamela J. Hornby, Orexin-A in the dorsal motor nucleus of the vagus potently increases gastric motor function via orexin 1 receptor in rats Gastroenterology. ,vol. 120, pp. A113- ,(2001) , 10.1016/S0016-5085(08)80556-2
Kaiko Kunii, Akihiro Yamanaka, Tadahiro Nambu, Ichiyo Matsuzaki, Katsutoshi Goto, Takeshi Sakurai, Orexins/hypocretins regulate drinking behaviour. Brain Research. ,vol. 842, pp. 256- 261 ,(1999) , 10.1016/S0006-8993(99)01884-3