Neurosteroid modulation of dendrodendritic inhibition in the mouse olfactory bulb.
作者： Mariko Usui , Yasuaki Kawasaki , Hideto Kaba
DOI: 10.1016/S0304-3940(99)00143-3
关键词: Olfactory bulb 、 Stimulation 、 Neuroactive steroid 、 Granule cell 、 Endocrinology 、 Internal medicine 、 Central nervous system 、 GABAergic 、 Chemistry 、 Olfactory system 、 Dendrodendritic synapse
摘要: The present report describes neurosteroid modulation of olfactory bulb function by examining the effects intrabulbar infusion dehydroepiandrosterone sulfate (DHEAS), a neurohormone discovered in rat brain, on field potentials granule cell layer evoked paired-pulse stimulation mouse lateral tract. Infusion DHEAS (5 nmol) significantly decreased test response without affecting conditioning response. As consequence, selectively potentiated depression, which is believed to be due cell-mediated inhibition mitral/tufted cells. granule-to-mitral/tufted dendrodendritic synapse GABAergic. Taken together, these results suggest that potentiates GABAergic exerted cells
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sci-hub.se 参考文章(20)
F. P. Monnet, V. Mahe, P. Robel, E. E. Baulieu, Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 3774- 3778 ,(1995) , 10.1073/PNAS.92.9.3774
Paul Q. Trombley, Gordon M. Shepherd, Synaptic transmission and modulation in the olfactory bulb Current Opinion in Neurobiology. ,vol. 3, pp. 540- 547 ,(1993) , 10.1016/0959-4388(93)90053-2
R. Guennoun, R.J. Fiddes, M. Gouézou, M. Lombès, E-E. Baulieu, A key enzyme in the biosynthesis of neurosteroids, 3β-hydroxysteroid dehydrogenase/Δ5-Δ4-isomerase (3β-HSD), is expressed in rat brain Molecular Brain Research. ,vol. 30, pp. 287- 300 ,(1995) , 10.1016/0169-328X(95)00016-L
Maria Dorota Majewska, Serdar Demirgo¨ren, Charles E. Spivak, Edythe D. London, The neurosteroid dehydroepiandrosterone sulfate is an allosteric antagonist of the GABAA receptor Brain Research. ,vol. 526, pp. 143- 146 ,(1990) , 10.1016/0006-8993(90)90261-9
C Corpéchot, B.E Collins, M.P Carey, A Tsouros, P Robel, J.P Fry, Brain neurosteroids during the mouse oestrous cycle Brain Research. ,vol. 766, pp. 276- 280 ,(1997) , 10.1016/S0006-8993(97)00749-X
J. F. Flood, J. E. Morley, E. Roberts, Pregnenolone sulfate enhances post-training memory processes when injected in very low doses into limbic system structures: the amygdala is by far the most sensitive. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 10806- 10810 ,(1995) , 10.1073/PNAS.92.23.10806
C Le Goascogne, P Robel, M Gouezou, N Sananes, E. Baulieu, M Waterman, Neurosteroids: cytochrome P-450scc in rat brain Science. ,vol. 237, pp. 1212- 1215 ,(1987) , 10.1126/SCIENCE.3306919
Jarlath M.H. ffrench-Mullen, Katherine T. Spence, Neurosteroids block Ca2+ channel current in freshly isolated hippocampal CA1 neurons European Journal of Pharmacology. ,vol. 202, pp. 269- 272 ,(1991) , 10.1016/0014-2999(91)90303-8
J. Young, C. Corpéchot, M. Haug, S. Gobaille, E.E. Baulieu, P. Robel, Suppressive effects of dehydroepiandrosterone and 3β-methyl-androst-5-en-17-one on attack towards lactating female intruders by castrated male mice. II. Brain neurosteroids Biochemical and Biophysical Research Communications. ,vol. 174, pp. 892- 897 ,(1991) , 10.1016/0006-291X(91)91501-3
Cheryl A. Frye, Kendall R. Van Keuren, Mary S. Erskine, Behavioral effects of 3α-androstanediol I: modulation of sexual receptivity and promotion of GABA-stimulated chloride flux Behavioural Brain Research. ,vol. 79, pp. 109- 118 ,(1996) , 10.1016/0166-4328(96)00004-6