Tumor-targeted biodegradable multifunctional nanoparticles for cancer theranostics
作者： Shuguang Yang , Liang Chen , Xiaojun Zhou , Ping Sun , Liwen Fu
DOI: 10.1016/J.CEJ.2019.122171
关键词: Nanocarriers 、 Epidermoid carcinoma 、 Doxorubicin Hydrochloride 、 Cancer research 、 Drug carrier 、 Mesoporous silica 、 Tumor microenvironment 、 Chemistry 、 Fluorescence-lifetime imaging microscopy 、 Cancer cell
摘要: Mesoporous silica nanoparticles (MSN) attract extensive attention in area of cancer diagnosis and therapy because of their controllable nanostructures, easy surface modification and stable synthesis methods. However, their biodegradability was still controversial. This work explored the degradation effect of a type of biodegradable MSN (bMSN) in different environments and simultaneously endowed it with imaging functions and high-efficiency targeting effect on cancer cell, thus forming a multifunctional biodegradable …
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