Gene Expression Profiles of Human Phosphotyrosine Phosphatases Consequent to Th1 Polarisation and Effector Function

摘要: Phosphotyrosine phosphatases (PTPs) constitute a complex family of enzymes that control the balance intracellular phosphorylation levels to allow cell responses while avoiding development diseases. Despite relevance CD4 T polarisation and effector function in human autoimmune diseases, expression profile PTPs during helper restimulation at inflammatory sites has not been assessed. Here, systematic analysis carried out Th1-polarising conditions upon PKC activation raise Ca2+ cells. Changes gene suggest previously nonnoted regulatory role several Th1 function. A substantial change spatial compartmentalisation ERK is proposed based on changes dose cytoplasmic nuclear MAPK phosphatases. Our study also suggests autoimmune-related controlling humans. We expect those regulate will potential targets for intervening immune order generate new therapies treatment