Imaging--the interface with pharmacology: looking to the future.

作者: Andrew J. Lawrence , Andreas Heinz

DOI: 10.1111/J.1476-5381.2011.01294.X

关键词: Basic researchImaging modalitiesMedical researchClinical pharmacologyMedicinePharmacologyMedical imagingPharmacological researchDrug discoveryInterface (computing)

摘要: Basic research is constantly adopting novel, innovative and powerful approaches to enable a deeper interrogation of the specific subject matter. A clear example this strategy development multiple imaging modalities, both in vitro vivo based, that have revolutionized medical research, drug discovery, diagnosis clinical monitoring. In themed section British Journal Pharmacology, we highlight number platforms which are discussed relation their applicability for pharmacological experiments, including longitudinal studies. As such, authors endeavour describe technology, its limitations how these can complement research. addition, there discussion role from perspective.

参考文章(16)
AR Finch, KR Sedgley, SP Armstrong, CJ Caunt, CA McArdle, Trafficking and signalling of gonadotrophin-releasing hormone receptors: an automated imaging approach British Journal of Pharmacology. ,vol. 159, pp. 751- 760 ,(2010) , 10.1111/J.1476-5381.2009.00413.X
Michael Patterson, Ryohei Yasuda, Signalling pathways underlying structural plasticity of dendritic spines British Journal of Pharmacology. ,vol. 163, pp. 1626- 1638 ,(2011) , 10.1111/J.1476-5381.2011.01328.X
CJ Daly, RA Ross, J Whyte, CM Henstridge, AJ Irving, JC McGrath, Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and ‘cannabinoid-like’ receptors in small arteries British Journal of Pharmacology. ,vol. 159, pp. 787- 796 ,(2010) , 10.1111/J.1476-5381.2009.00608.X
James T Russell, Imaging calcium signals in vivo: a powerful tool in physiology and pharmacology British Journal of Pharmacology. ,vol. 163, pp. 1605- 1625 ,(2011) , 10.1111/J.1476-5381.2010.00988.X
Peter Johnström, Tim D Fryer, Hugh K Richards, Janet J Maguire, John C Clark, John D Pickard, Anthony P Davenport, Positron emission tomography of [18F]-big endothelin-1 reveals renal excretion but tissue-specific conversion to [18F]-endothelin-1 in lung and liver British Journal of Pharmacology. ,vol. 159, pp. 812- 819 ,(2010) , 10.1111/J.1476-5381.2010.00641.X
F Ortolano, P Maffia, G Dever, G Rodolico, OR Millington, MG De Simoni, JM Brewer, TJ Bushell, P Garside, HV Carswell, Advances in imaging of new targets for pharmacological intervention in stroke: real time tracking of T cells in the ischaemic brain British Journal of Pharmacology. ,vol. 159, pp. 808- 811 ,(2010) , 10.1111/J.1476-5381.2009.00527.X
Rachel H Rose, Stephen J Briddon, Nicholas D Holliday, None, Bimolecular fluorescence complementation: lighting up seven transmembrane domain receptor signalling networks British Journal of Pharmacology. ,vol. 159, pp. 738- 750 ,(2010) , 10.1111/J.1476-5381.2009.00480.X
James AG Kennard, Keith L Brain, Lauren K Parker, Julia A Shanks, Dynamic monitoring of NET activity in mature murine sympathetic terminals using a fluorescent substrate British Journal of Pharmacology. ,vol. 159, pp. 797- 807 ,(2010) , 10.1111/J.1476-5381.2009.00574.X
Patrick Baril, Pilar Martin-Duque, Georges Vassaux, Visualization of gene expression in the live subject using the Na/I symporter as a reporter gene: applications in biotherapy. British Journal of Pharmacology. ,vol. 159, pp. 761- 771 ,(2010) , 10.1111/J.1476-5381.2009.00412.X
Jillian G Baker, Richard Middleton, Luke Adams, Lauren T May, Stephen J Briddon, Barrie Kellam, Stephen J Hill, None, Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A1 receptor ligands. British Journal of Pharmacology. ,vol. 159, pp. 772- 786 ,(2010) , 10.1111/J.1476-5381.2009.00488.X