Hypermethylation of the RECK gene predicts poor prognosis in oral squamous cell carcinomas.
作者： Nguyen Khanh Long , Keizo Kato , Tomomi Yamashita , Hiroki Makita , Makoto Toida
DOI: 10.1016/J.ORALONCOLOGY.2008.02.004
关键词: Methylation 、 Pathology 、 Cancer 、 Biology 、 Cell 、 Primary tumor 、 DNA methylation 、 Tumor suppressor gene 、 Cancer research 、 Metastasis 、 Biomarker (medicine)
摘要: Summary The RECK gene is a novel tumor suppressor that regulates matrix metalloproteinases (MMPs) to inhibit angiogenesis, invasion and metastasis. We investigated the methylation status of in 40 primary oral squamous cell carcinomas (OSCC) 20 paired adjacent normal mucosa by methylation-specific PCR. Furthermore, we determined prognostic importance hypermethylation OSCC patients. Our findings showed was methylated 52.5% (21 40) OSCC. Among cases with corresponding tissues, detected both (55%, 11 20) (30%, 6 20). Methylation not all samples 12 healthy controls. In univariate analysis, inversely correlated recurrence-free survival ( p = 0.027) overall = 0.023) Multivariate analysis only independent factor affecting = 0.037). result indicates promoter common event human OSCC, occurs concurrently tumor–adjacent poor prognosis Although additional work needed, promising biomarker early detection for cancer
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