Early Responses of Natural Killer Cells in Pigs Experimentally Infected with 2009 Pandemic H1N1 Influenza A Virus

摘要: Natural killer (NK) cells are important players in the innate immune response against influenza A virus and activating receptor NKp46, which binds hemagglutinin on surface of infected cells, has been assigned a role this context. As pigs natural hosts for viruses possess both NKp46− NKp46+ NK they represent good animal model studying NKp46 during influenza. We explored piglets experimentally with 2009 pandemic H1N1 by flow cytometric analyses isolated from blood lung tissue immunostaining sections. The number was reduced while remained unaltered 1–3 days after infection. In lungs, intensity expression increased first 3 days, areas where nucleoprotein detected were associated numbers when compared to uninfected areas. neither found be nor undergoing apoptosis. binding porcine verified an vitro assay. These data support involvement local virus.