Interactive Effects of Verapamil and Sympathetic Nerve Stimulation on the Sinus and AV Nodes in the Canine Hearts.
作者： Katsusuke YANO , Masanobu HIRATA , Takao MITSUOKA , Yoriaki MATSUMOTO , Tetsuya HIRATA
DOI: 10.1536/IHJ.33.83
关键词: Anesthesia 、 Verapamil 、 Fissipedia 、 Electrophysiology 、 Stimulation 、 Atrioventricular node 、 Stellate ganglion 、 Sinus (anatomy) 、 Carnivora 、 Medicine
摘要: The interactive effects of verapamil and sympathetic nerve stimulation on the sinus atrioventricular (AV) nodes were studied in 33 bilaterally stellectomized vagotomized dogs. Sinus cycle length (SCL) AV nodal conduction time (AH) at a constant drive (600 msec) recorded. Sympathetic (SNS) was performed for 40 sec by electrical right stellate ganglion. Several doses (0.5-2.0μg/ml, 1.0ml) injected directly into node arteries 20 SNS. In addition, SNS repeated two different intensities after administration. Verapamil significantly increased SCL AH dose dependent fashion, which reduced reductions attenuated presence when intensity weak, but not strong. It is concluded that activity interact antagonistically automaticity conduction.
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