Photobiomodulation reduces abdominal adipose tissue inflammatory infiltrate of diet-induced obese and hyperglycemic mice.

摘要: PBM on obese and hyperglycemic mice reduced five times the areas of inflammatory infiltrate within abdominal adipose tissue (a, b), whereas dense regions were a common finding amidst non-irradiated animals (c). The asterisks (c) correspond to permeating adipocytes. Systemic inflammation is closely related development insulin resistance type-2 diabetes, since activation pro-inflammatory pathways leads inhibition signaling. Although photobiomodulation (PBM) has proven beneficial effects treatment disorders, phototherapeutic approach manage chronic component obesity hyperglycemia had never been explored. In this work, are treated with PBM, their body mass, glycemia evaluated. During four weeks, irradiated exposed six irradiation sessions using an 843 nm LED (5.7 J cm–2 at 19 mW cm–2 per session). Non-irradiated control display almost greater than group (p < 0.001). This result may have caused impacts significant lower blood glucose level from (p = 0.04), twenty-four hours after last session.