Effects of functional interactions between nonhomologous insulators Wari and Su(Hw)
作者： M. M. Erokhin , P. G. Georgiev , D. A. Chetverina
DOI: 10.1134/S1022795410010035
关键词: Genetics 、 Insulator (electricity) 、 Chromatin Loop 、 Biology 、 Chemical physics
摘要: Insulators are regulatory DNA elements restricting gene activation by enhancers. Interactions between insulators can lead to both insulation and of promoters In this work, we analyzed the effects interaction two Drosophila insulators, Wari Su(Hw). The functional these was found enhance activity Su(Hw) insulator only, but not insulator. This suggests that formation a chromatin loop interacting is key factor for enhancement insulation, which in disagreement with main idea structural models. addition, effect depends on distance them position system relative other elements.
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