Prediction of breast cancer using volatile biomarkers in the breath
作者： Michael Phillips , Renee N. Cataneo , Beth Ann Ditkoff , Peter Fisher , Joel Greenberg
DOI: 10.1007/S10549-006-9176-1
关键词: Asymptomatic 、 Random assignment 、 Case-control study 、 Surgery 、 Biopsy 、 Breath test 、 Cancer 、 Prospective cohort study 、 Breast cancer 、 Oncology 、 Medicine 、 Internal medicine
摘要: We evaluated a breath test for volatile organic compounds (VOCs) as predictor of breast cancer. Breath VOCs were assayed in 51 asymptomatic women with abnormal mammograms and biopsy-proven cancer, 42 age-matched healthy women. A fuzzy logic model predicted cancer accuracy superior to previously reported findings. Following random assignment training set (64) or prediction (29), was constructed the employing five that 93.8% sensitivity 84.6% specificity. The same no 16/50 (32.0%) on biopsy. two-minute could potentially provide safe, accurate painless screening but prospective validation studies are required.
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Ernest Hamel, Chii M. Lin, Jacqueline Plowman, Hui-Kang Wang, Kuo-Hsiung Lee, Kenneth D. Paull, Antitumor 2,3-dihydro-2-(aryl)-4(1H)-quinazolinone derivatives. Interactions with tubulin. Biochemical Pharmacology. ,vol. 51, pp. 53- 59 ,(1996) , 10.1016/0006-2952(95)02156-6
Hans-Georg Velcovsky, Erich Eigenbrodt, Gregor Peltri, Joachim Schneider, Kathleen Neu, Norbert Katz, Norman Bitterlich, Harald Morr, Fuzzy logic-based tumor marker profiles including a new marker tumor M2-PK improved sensitivity to the detection of progression in lung cancer patients. Anticancer Research. ,vol. 23, pp. 899- 906 ,(2003)
S Ciatto, M Rosselli Del Turco, P Burke, C Visioli, E Paci, M Zappa, Comparison of standard and double reading and computer-aided detection (CAD) of interval cancers at prior negative screening mammograms: blind review. British Journal of Cancer. ,vol. 89, pp. 1645- 1649 ,(2003) , 10.1038/SJ.BJC.6601356
Michael Phillips, John P. Boehmer, Renee N. Cataneo, Taseer Cheema, Howard J. Eisen, John T. Fallon, Peter E. Fisher, Alan Gass, Joel Greenberg, Jon Kobashigawa, Donna Mancini, Barry Rayburn, Mark J. Zucker, Prediction of heart transplant rejection with a breath test for markers of oxidative stress. American Journal of Cardiology. ,vol. 94, pp. 1593- 1594 ,(2004) , 10.1016/J.AMJCARD.2004.08.052
Ilan Modai, Julia Kuperman, Imri Goldberg, Michael Goldish, Shalom Mendel, Fuzzy logic detection of medically serious suicide attempt records in major psychiatric disorders. Journal of Nervous and Mental Disease. ,vol. 192, pp. 708- 710 ,(2004) , 10.1097/01.NMD.0000142020.20038.DD
Shubhasish Mukherjee, Vijayendra Kumar, Ashok K. Prasad, Hanumantharao G. Raj, Marc E. Bracke, Carl E. Olsen, Subhash C. Jain, Virinder S. Parmar, Synthetic and biological activity evaluation studies on novel 1,3-diarylpropenones. Bioorganic & Medicinal Chemistry. ,vol. 9, pp. 337- 345 ,(2001) , 10.1016/S0968-0896(00)00249-2
Mehrdad Yazdanpanah, Xiaoping Luo, Robert Lau, Mark Greenberg, Lawrence J Fisher, Denis C Lehotay, Cytotoxic Aldehydes as Possible Markers for Childhood Cancer Free Radical Biology and Medicine. ,vol. 23, pp. 870- 878 ,(1997) , 10.1016/S0891-5849(97)00070-1
Michael Phillips, Renee N Cataneo, Taseer Cheema, Joel Greenberg, Increased breath biomarkers of oxidative stress in diabetes mellitus Clinica Chimica Acta. ,vol. 344, pp. 189- 194 ,(2004) , 10.1016/J.CCCN.2004.02.025
Michael Phillips, Renee N. Cataneo, Andrew R.C. Cummin, Anthony J. Gagliardi, Kevin Gleeson, Joel Greenberg, Roger A. Maxfield, William N. Rom, Detection of lung cancer with volatile markers in the breath Chest. ,vol. 123, pp. 2115- 2123 ,(2003) , 10.1378/CHEST.123.6.2115
Michael Phillips, Method for the Collection and Assay of Volatile Organic Compounds in Breath Analytical Biochemistry. ,vol. 247, pp. 272- 278 ,(1997) , 10.1006/ABIO.1997.2069