Austrian Moderate Altitude Study 2000 (AMAS 2000). The effects of moderate altitude (1,700 m) on cardiovascular and metabolic variables in patients with metabolic syndrome.

摘要: We investigated the changes in cardiovascular system [resting blood pressure (BP) and heart rate (HR), measured by means of a 24-h ambulatory BP holter-electrocardiogram (ECG)], glycemic parameters, lipid metabolism subjects suffering from metabolic syndrome during 3-week sojourn at 1,700 m Austrian Alps. A total 22 male with were selected. Baseline investigations performed Innsbruck (500 m above sea level). During altitude stay participants simulated holiday moderate sports activities. Examinations on days 1, 4, 9, 19. After returning to Innsbruck, post-altitude examinations conducted after 7–10 days 6–7 weeks, respectively. The holter ECG revealed decrease average HR, BP, product (RPP: systolic × HR) 3 weeks exposure. In some patients, an increase premature ventricular beats was observed end compared beginning exposure altitude. no ischemic ST-segment changes. Maximal physical capacity as symptom-limited maximal cycle ergometry tests remained unchanged study. Six weeks increased again returned pretest levels. Homeostasis Model Assessment index, which is measure insulin resistance, decreased significantly glucose concentrations obtained oral tolerance test lower basal values. conclude that altitude, patients (1) tolerated their without any problems, (2) exhibited short-term favorable effects system, (3) had significant improvements parameters paralleled high-density-lipoprotein-cholesterol.