Effect of topical naltrexone 0.3% on corneal sensitivity and tear parameters in normal brachycephalic dogs

摘要: Objective To determine the effect of topical naltrexone 0.3% on tear production, corneal sensitivity, and film stability in normal brachycephalic dogs. Animals Studied Twenty-two dogs. Procedures Measurements production (Schirmer test I II), intraocular pressure (IOP), central sensitivity (CS), breakup time (TFBUT) were collected at 0, 1, 24 h after administration either (NTX) or placebo (SV). Naltrexone SV was then administered once daily for 1 week, above measurements repeated 7 days, again 7 days discontinuing medication. Owners scored degree comfort, redness, rubbing, squinting, tearing. Serum 24 h, to systemic concentrations. Results Owners reported no significant change detected serum all treated dogs 1-h postadministration (average: 908 pg/mL, range: 319–1570 pg/mL) two 1-week point. not 24-h There NTX STT1, STT2, IOP, CS, TFBUT. Conclusions Naltrexone is well tolerated safe when applied topically eye daily. did show any effects parameters as measured this study. At once, dosing systemically absorbed; however, absorption likely be clinically significant.