Distinct Regulatory Cascades Govern Extraocular and Pharyngeal Arch Muscle Progenitor Cell Fates

摘要: Genetic regulatory networks governing skeletal myogenesis in the body are well understood, yet their hierarchical relationships head remain unresolved. We show that either Myf5 or Mrf4 is necessary for initiating extraocular myogenesis. Whereas dispensable pharyngeal muscle progenitor fate, Tbx1 and act synergistically this location. As body, Myod acts epistatically to cascades head. Thus, complementary pathways, governed by Pax3 muscles, but absent activate core myogenic network. These diverse progenitors maintain respective embryonic signatures adult. However, these not sufficient ensure specific phenotypes, since expected differentiated phenotype manifested when satellite cells engrafted heterotopically. findings identify novel genetic may provide insights into myopathies which often affect only subsets of muscles.