Hypothalamic obesity : The autonomic hypothesis and the lateral hypothalamus.

摘要: Several lines of evidence support the hypothesis that derangements in function autonomic nervous system play an important role development hypothalamic obesity. Vagotomy below diaphragm, reverses syndrome. In diabetic rats cured their diabetes with transplants fetal pancreatic tissue beneath renal capsule, ventromedial (VMH) lesions do not produce characteristic rise food intake nor they significantly increase serum insulin. These observations indicate hyperinsulinaemia following VMH is result neural connections rather than from a circulating humoral factor released injury. The smaller salivary glands, reduced level glucagon and impaired mobilization fatty acids during stress lesioned point to activity sympathetic system. fat retroperitoneal depots fasting similar effect denervation pad. Similarly, unilateral sympathectomy caused increased weight gain almost as much but less bilaterally rats. studies feeding implicate control When atropine epinephrine were given rats, there was significant depression basal glucose-stimulated levels Finally when placed after lateral lesions, did seem be reduced, suggesting two effects are independent. A model dealing presented attempt integrate these findings.