Selenols: a new class of carbonic anhydrase inhibitors.
作者： A. Angeli , M. Ferraroni
DOI: 10.2210/PDB6HWZ/PDB
关键词: Lyase 、 Carbonic anhydrase 、 Binding site 、 Aryl 、 Plasma protein binding 、 Stereochemistry 、 Chemistry
摘要: Stable aryl selenols were obtained through a convenient procedure. Selenols represent new chemotype acting as carbonic anhydrase inhibitors (CAIs), inhibiting four human isoforms, CAs I, II, VII and the tumor-associated CA IX. X-ray crystallographic, physical computational studies provided insights into binding mode of this conceptually class CAIs.
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