Embryonic Stem Cells: A Perspective

作者: Martin Evans

DOI: 10.1002/0470091452.CH8

关键词: Adult stem cellStem cellCell biologyHomeobox protein NANOGAmniotic epithelial cellsInduced pluripotent stem cellKOSREmbryoid bodyEmbryonic stem cellBiology

摘要: Embryonic stem (ES) cells are proliferating tissue-culture which embryonic in origin and retain the full lineage differentiative capacity of early mammalian embryo. Only mouse ES have been fully characterized but similar cultures isolated from numbers other embryos including, notably, human. can differentiate either vivo context an embryo or equivalently vitro. Their ability to undergo genetic alteration selection vitro followed by development has led their extensive use as a vector for engineering. This is not application human into plethora specific tissue precursors scenarios cellular engineering therapies. Ethical practical problems provision ad hominem remain. Knowledge system may aid our understanding relationship between embryos.

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