Tetrazine-Norbornene Click Reactions to Functionalize Degradable Polymers Derived from Lactide
作者： Ian A. Barker , Daniel J. Hall , Claire F. Hansell , Filip E. Du Prez , Rachel K. O'Reilly
关键词: Ring-opening polymerization 、 Ene reaction 、 Tetrazine 、 Lactide 、 Materials science 、 Polymer chemistry 、 Norbornene 、 Click chemistry 、 Polymer 、 Copolymer 、 Organic chemistry 、 Materials Chemistry 、 Polymers and Plastics
摘要: Post-polymerization modification of polymers derived from sustainable resources using the click reaction between tetrazines and norbornenes is shown to provide a mild efficient route for synthesis functional degradable polymers. Norbornene chain-end poly(lactide) was synthesized organocatalytic methods functionalized by addition 3,6-di-2-pyridyl-1,2,4,5-tetrazine without degradation polymer backbone. The versatility this demonstrated application analogues bearing amine poly(ethylene oxide) groups realize amine-functional block copolymers. Poly(spiro[6-methyl-1,4-dioxane-2,5-dione-3,2'-bicyclo[2.2.1]hept[5]ene]) prepared lactide. pendant norbornene group on backbone resultant modified in similar manner produce graft co-polymers.
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