Quantitative Measures of Visceral Adiposity and Body Mass Index in Predicting Rectal Cancer Outcomes after Neoadjuvant Chemoradiation

摘要: Background The association between body mass index as a measure of obesity and rectal cancer outcomes has been inconsistent. Radiologic measures visceral adiposity using CT scans have not well characterized among patients. objective this study was to examine quantitative radiologic compared with in predicting patient patients undergoing neoadjuvant chemoradiation resection for locally advanced cancers. Study Design We identified 99 adenocarcinoma treated surgical resection. Visceral subcutaneous fat areas, perinephric thickness (PNF), were recorded categorized obese (body ≥30, area ratio [V/S] ≥0.4, or median PNF). Kaplan-Meier method, log-rank test, Cox proportional hazards models evaluated overall disease-free survival differences by adiposity. Results Viscerally (V/S >0.4 PNF) more likely be older, male, pre-existing obesity-related conditions (eg, diabetes, hypertension, and/or hypercholesterolemia). Elevated V/S PNF associated shorter (p = 0.02) time (p = 0.047), respectively. Among moderately differentiated tumors, poorer >0.4: adjusted hazard ratio = 5.0; 95% CI, 1.2–22.0). Conclusions strongly key preoperative metabolic comorbidities, not. Findings suggests that elevated an increased risk recurrence, which most evident tumors those incomplete response treatment. Quantitative warrant large-scale prospective evaluation.