Diarylsulfonylureas : new anticancer agents with novel activities, toxicities and mechanism of action

摘要: The diarylsulfonylureas (DSU’s) represent a novel class of antitumor agents that were identified as active against rodent solid tumors, but not leukemias [1, 2]. We subsequently demonstrated activity human tumor xenografts [3] and notably from colon adenocarcinomas refractory to other used in clinical therapy. At the same time, pre-clinical toxicology, undertaken by Eli Lilly Company, showed major toxicities rodents primates was limited hemolytic anemia methemoglobinemia. Thus, spectrum activity, pattern toxicity prompted this laboratory examine, detail, mechanism(s) action compound. In article some more interesting preclinical data with DSU’s are presented.