Neuropsychiatric systemic lupus erythematosus.

摘要: Neuropsychiatric systemic lupus erythematosus (NPSLE) is the least understood, yet perhaps most prevalent manifestation of lupus. The pathogenesis NPSLE multifactorial and involves various inflammatory cytokines, autoantibodies, immune complexes resulting in vasculopathic, cytotoxic autoantibody-mediated neuronal injury. management multimodal has not been subjected to rigorous study. Different treatment regimens include nonsteroidal anti-inflammatory drugs, anticoagulation, immunosuppressives such as cyclophosphamide, azathioprine, mycophenolate mofetil, methotrexate. For refractory NPSLE, intravenous immunoglobulin (IVIG), plasmapheresis, rituximab have used. Adjunctive symptomatic complements these therapies by targeting mood disorders, psychosis, cognitive impairment, seizures or headaches. Several new biological agents are being tested including Belimumab, a human monoclonal antibody that targets B lymphocyte stimulator. This review focuses on pathophysiology, treatment, potential for neuropsychiatric manifestations erythematosus.