Using proteomics in perinatal and neonatal sepsis: hopes and challenges for the future.

作者: Catalin S Buhimschi , Vineet Bhandari , Yiping W Han , Antonette T Dulay , Margaret A Baumbusch

DOI: 10.1097/QCO.0B013E32832A5963

关键词: Neonatal sepsisProteomicsInflammationImmunologyImmune systemMedicineInfant newbornSepsisBioinformaticsBiochemical markersFetus

摘要: Purpose of reviewParticularities the fetal immune response to infection cause a heightened inflammatory state that acts synergistically with microbial insult induce damage. Proteomics offers opportunity for detecting fetuses at risk sepsis and neurological injury.Recent findingsMolecula

参考文章(94)
Janyne E. Althaus, Ernest M. Graham, Maggie C. Blakemore, Elizabeth A. Johnson, Abimbola J. Aina-Mumuney, Janice L. Henderson, Intrapartum electronic fetal monitoring and the identification of systemic fetal inflammation. Journal of Reproductive Medicine. ,vol. 52, pp. 762- 768 ,(2007)
Jeanne A. Jordan, Mary Beth Durso, Allyson R. Butchko, Judith G. Jones, Beverly S. Brozanski, Evaluating the near-term infant for early onset sepsis: progress and challenges to consider with 16S rDNA polymerase chain reaction testing. The Journal of Molecular Diagnostics. ,vol. 8, pp. 357- 363 ,(2006) , 10.2353/JMOLDX.2006.050138
Hyagriv N. Simhan, Timothy P. Canavan, Preterm premature rupture of membranes: diagnosis, evaluation and management strategies. British Journal of Obstetrics and Gynaecology. ,vol. 112, pp. 32- 37 ,(2005) , 10.1111/J.1471-0528.2005.00582.X
Mark S. Wainwright, Linda J. Van Eldik, The Janus face of glial-derived S100B: beneficial and detrimental functions in the brain. Restorative Neurology and Neuroscience. ,vol. 21, pp. 97- 108 ,(2003)
Michael Fountoulakis, Jean-François Juranville, Mara Dierssen, Gert Lubec, Proteomic analysis of the fetal brain Proteomics. ,vol. 2, pp. 1547- 1576 ,(2002) , 10.1002/1615-9861(200211)2:11<1547::AID-PROT1547>3.0.CO;2-M
Robert L. Goldenberg, William W. Andrews, Alice R. Goepfert, Ona Faye-Petersen, Suzanne P. Cliver, Waldemar A. Carlo, John C. Hauth, The Alabama Preterm Birth Study: Umbilical cord blood Ureaplasma urealyticum and Mycoplasma hominis cultures in very preterm newborn infants American Journal of Obstetrics and Gynecology. ,vol. 198, pp. 43- 45 ,(2008) , 10.1016/J.AJOG.2007.07.033
Susan Bernstein, Ruth Heimler, P. Sasidharan, Approaching the management of the neonatal intensive care unit graduate through history and physical assessment Pediatric Clinics of North America. ,vol. 45, pp. 79- 105 ,(1998) , 10.1016/S0031-3955(05)70584-8
M. J. Bizzarro, L.-M. Dembry, R. S. Baltimore, P. G. Gallagher, Changing Patterns in Neonatal Escherichia coli Sepsis and Ampicillin Resistance in the Era of Intrapartum Antibiotic Prophylaxis Pediatrics. ,vol. 121, pp. 689- 696 ,(2008) , 10.1542/PEDS.2007-2171
Irina A. Buhimschi, Rob Christner, Catalin S. Buhimschi, Proteomic biomarker analysis of amniotic fluid for identification of intra-amniotic inflammation. British Journal of Obstetrics and Gynaecology. ,vol. 112, pp. 173- 181 ,(2005) , 10.1111/J.1471-0528.2004.00340.X
Pak C. Ng, Hugh S. Lam, Diagnostic markers for neonatal sepsis Current Opinion in Pediatrics. ,vol. 18, pp. 125- 131 ,(2006) , 10.1097/01.MOP.0000193293.87022.4C