Tuning Size and Morphology of mPEG-b-p(HPMA-Bz) Copolymer Self-Assemblies Using Microfluidics.

摘要: The careful design of nanoparticles, in terms size and morphology, is great importance to developing effective drug delivery systems. ability precisely tailor nanoparticles morphology during polymer self-assembly was therefore investigated. Four poly(ethylene glycol)-b-poly(N-2-benzoyloxypropyl methacrylamide) mPEG-b-p(HPMA-Bz) block copolymers with a fixed hydrophilic mPEG 5 kDa varying molecular weight the hydrophobic p(HPMA-Bz) (A: 17.1, B: 10.0, C: 5.2 D: 2.7 kDa) were self-assembled into by nanoprecipitation under well-defined flow conditions, using microfluidics, at different concentrations. from A, increased 55 90 nm lower concentrations slower rates even vesicles formed along micelles. Similarly, D 35 70 also micelles, regardless used concentration. Differently, polymers B C mainly micelles applied negligible difference. In conclusion, this study demonstrates that can be easily tailored microfluidics an attractive option for further scaled-up production activities.