DEXAMETHASONE AND CORTICOSTERONE INDUCE SIMILAR, BUT NOT IDENTICAL, MUSCLE WASTING RESPONSES IN CULTURED L6 AND C2C12 MYOTUBES

作者: Michael Menconi , Patricia Gonnella , Victoria Petkova , Stewart Lecker , Per-Olof Hasselgren

DOI: 10.1002/JCB.21833

关键词: Protein degradationGlucocorticoidGlucocorticoid receptorInternal medicineC2C12CorticosteroneEndocrinologyMyogenesisCell typeDexamethasoneBiology

摘要: … of the GR in both L6 and C2C12 myotubes. The GR antagonist RU38486 inhibited the … but not in C2C12 myotubes. Interestingly, RU38486 exerted agonist effects in the C2C12, but not …

参考文章(62)
Thorpe Sd, Byers Fm, Gunn Jm, Schelling Gt, Roeder Ra, Influence of anabolic agents on protein synthesis and degradation in muscle cells grown in culture. Growth. ,vol. 50, pp. 485- ,(1986)
M M Desler, S J Jones, C W Smith, T L Woods, Effects of dexamethasone and anabolic agents on proliferation and protein synthesis and degradation in C2C12 myogenic cells. Journal of Animal Science. ,vol. 74, pp. 1265- 1273 ,(1996) , 10.2527/1996.7461265X
Arkadiusz Orzechowski, Michał Jank, Barbara Gajkowska, Tomasz Sadkowski, Michał Marek Godlewski, Piotr Ostaszewski, None, Delineation of signalling pathway leading to antioxidant-dependent inhibition of dexamethasone-mediated muscle cell death. Journal of Muscle Research and Cell Motility. ,vol. 24, pp. 33- 53 ,(2003) , 10.1023/A:1024887431768
Etienne-Emile Baulieu, Paul A. Kelly, Hormones : from molecules to disease Hermann , Chapman and Hall. ,(1990)
Arianna Dellavalle, Maurilio Sampaolesi, Rossana Tonlorenzi, Enrico Tagliafico, Benedetto Sacchetti, Laura Perani, Anna Innocenzi, Beatriz G. Galvez, Graziella Messina, Roberta Morosetti, Sheng Li, Marzia Belicchi, Giuseppe Peretti, Jeffrey S. Chamberlain, Woodring E. Wright, Yvan Torrente, Stefano Ferrari, Paolo Bianco, Giulio Cossu, Pericytes of human skeletal muscle are myogenic precursors distinct from satellite cells. Nature Cell Biology. ,vol. 9, pp. 255- 267 ,(2007) , 10.1038/NCB1542
Anne C. Marinovic, Bin Zheng, William E. Mitch, S. Russ Price, Tissue-specific regulation of ubiquitin (UbC) transcription by glucocorticoids: in vivo and in vitro analyses. American Journal of Physiology-renal Physiology. ,vol. 292, ,(2007) , 10.1152/AJPRENAL.00178.2006
Miroslava T. Vujčić, Nataša Veličković, Sabera Ruždijić, Dexamethasone treatment affects nuclear glucocorticoid receptor and glucocorticoid response element binding activity in liver of rats (Rattus norvegicus) during aging. Comparative Biochemistry and Physiology B. ,vol. 148, pp. 463- 469 ,(2007) , 10.1016/J.CBPB.2007.07.090
Trevor N. Stitt, Doreen Drujan, Brian A. Clarke, Frank Panaro, Yekatarina Timofeyva, William O. Kline, Michael Gonzalez, George D. Yancopoulos, David J. Glass, The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. Molecular Cell. ,vol. 14, pp. 395- 403 ,(2004) , 10.1016/S1097-2765(04)00211-4
Maria Klaude, Katarina Fredriksson, Inga Tjäder, Folke Hammarqvist, Bo Ahlman, Olav Rooyackers, Jan Wernerman, Proteasome proteolytic activity in skeletal muscle is increased in patients with sepsis. Clinical Science. ,vol. 112, pp. 499- 506 ,(2007) , 10.1042/CS20060265