Genetics of basal cell carcinoma
作者： Sally E De Zwaan , Nikolas K Haass
DOI: 10.1111/J.1440-0960.2009.00579.X
关键词: DNA repair 、 PTCH1 、 Biology 、 Cancer 、 Hedgehog signaling pathway 、 Genetics 、 Patched 、 Genetic predisposition 、 Basal cell carcinoma 、 Carcinogenesis
摘要: Basal cell carcinoma is the most common human malignancy in populations of European origin, and Australia has highest incidence basal world. Great advances understanding genetics this cancer have occurred recent years. Mutations patched 1 gene (PTCH1) lead to predisposition Gorlin syndrome. PTCH1 part hedgehog signalling pathway, derangements within pathway are now known be important carcinogenesis many different cancers including sporadic carcinoma. The molecular biology discussed, mouse models based on explored. New developments non-surgical treatment knowledge. Other genes importance development include tumour suppressor P53 melanocortin-1 receptor gene. In addition, we discuss molecules possible such as glutathione-S-transferases, DNA repair genes, cyclin-dependent kinase inhibitor 2A, Brahma connexins. Evidence familial aggregation explored supports possibility genetic malignancy.
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