Pharmacological effects of 3-iodothyronamine (T1AM) in mice include facilitation of memory acquisition and retention and reduction of pain threshold

摘要: Background and Purpose 3-Iodothyronamine (T1AM), an endogenous derivative of thyroid hormones, is regarded as a rapid modulator behaviour metabolism. To determine whether brain hormone levels contribute to these effects, we investigated the effect central administration T1AM on learning pain threshold mice either untreated or pretreated with clorgyline (2.5 mg·kg−1, i.p.), inhibitor amine oxidative metabolism. Experimental Approach T1AM (0.13, 0.4, 1.32 4 μg·kg−1) vehicle was injected i.c.v. into male mice, after 30 min their effects memory acquisition capacity, curiosity were evaluated by following tests: passive avoidance, licking latency hot plate movements hole-board platform. Plasma glycaemia measured using glucorefractometer. Brain triiodothyroxine (T3), thyroxine (T4) HPLC coupled tandem MS. ERK1/2 activation c-fos expression in different regions Western blot analysis. Results T1AM improved decreased stimuli, enhanced raised plasma dose-dependent way, without modifying T3 T4 concentrations. abolished significantly affected clorgyline, suggesting role for some metabolite(s), that interacts at desensitizing target(s). activated ERK areas lower doses than those effective behaviour. Conclusions And Implications T1AM novel enhancer. This feature might have important implications treatment endocrine neurodegenerative-induced disorders.