Association of CT60 cytotoxic T lymphocyte antigen‐4 gene polymorphism with thyroid autoantibody production in patients with Hashimoto's and postpartum thyroiditis
作者： K. Zaletel , B. Krhin , S. Gaberšček , A. Biček , T. Pajič
DOI: 10.1111/J.1365-2249.2010.04113.X
关键词: Thyroid peroxidase 、 Autoantibody 、 Postpartum thyroiditis 、 Immunology 、 Thyroid 、 Anti-thyroid autoantibodies 、 Medicine 、 Thyroid function 、 Thyroiditis 、 Endocrinology 、 Internal medicine 、 Thyroglobulin
摘要: Strong genetic contribution has been demonstrated to influence the development of autoimmune thyroid disease (AITD) as well autoantibody production. In order assess relation between CT60 cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism and production, we investigated 180 consecutive newly diagnosed patients with two forms AITD, 105 Hashimoto's thyroiditis (HT) 75 postpartum (PPT). We evaluated function, measured antibodies against peroxidase (TPO) thyroglobulin (Tg), determined CTLA-4 polymorphism. HT, TPO antibody median value was significantly lower in AA compared AG GG genotypes (65, 122 319 U/ml, P<0.005), while Tg genotype (91 189 P<0.02). PPT, frequency autoantibody-positive higher among G-allele-carrying (P<0.04). Similar (12, 130 423 P<0.006). Hypothyroid PPT were more often (P<0.005) hyperthyroid (500 32 P<0.0001). The G-allele hypothyroid (P<0.05). Our data suggest that both HT contributes importantly also seems polymorphous allele are prone develop form PPT.
blackwell-synergy.com参考文章(36)
R. Hall, J. B. Stanbury, Familial studies of autoimmune thyroiditis. Clinical and Experimental Immunology. ,vol. 2, pp. 719- ,(1967)
Hironori Ueda, Joanna MM Howson, Laura Esposito, Joanne Heward, Snook, Giselle Chamberlain, Daniel B Rainbow, Kara MD Hunter, Annabel N Smith, Gianfranco Di Genova, Mathias H Herr, Ingrid Dahlman, Felicity Payne, Deborah Smyth, Christopher Lowe, Rebecca CJ Twells, Sarah Howlett, Barry Healy, Sarah Nutland, Helen E Rance, Vin Everett, Luc J Smink, Alex C Lam, Heather J Cordell, Neil M Walker, Cristina Bordin, John Hulme, Costantino Motzo, Francesco Cucca, J Fred Hess, Michael L Metzker, Jane Rogers, Simon Gregory, Amit Allahabadia, Ratnasingam Nithiyananthan, Eva Tuomilehto-Wolf, Jaakko Tuomilehto, Polly Bingley, Kathleen M Gillespie, Dag E Undlien, Kjersti S Rønningen, Cristian Guja, Constantin Ionescu-Tîrgovişte, David A Savage, A Peter Maxwell, Dennis J Carson, Chris C Patterson, Jayne A Franklyn, David G Clayton, Laurence B Peterson, Linda S Wicker, John A Todd, Stephen CL Gough, None, Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease Nature. ,vol. 423, pp. 506- 511 ,(2003) , 10.1038/NATURE01621
L.D.K.E. Premawardhana, A.B. Parkes, R. John, B. Harris, J.H. Lazarus, Thyroid Peroxidase Antibodies in Early Pregnancy: Utility for Prediction of Postpartum Thyroid Dysfunction and Implications for Screening Thyroid. ,vol. 14, pp. 610- 615 ,(2004) , 10.1089/1050725041692828
T.G.A. Strieder, M.F. Prummel, E. Endert, J.G.P. Tijssen, W.M. Wiersinga, Risk factors for and prevalence of thyroid disorders in a cross-sectional study among healthy female relatives of patients with autoimmune thyroid disease Experimental and Clinical Endocrinology & Diabetes. ,vol. 59, pp. 396- 401 ,(2003)
Yaron Tomer, David A. Greenberg, Giuseppe Barbesino, Erlinda Concepcion, Terry F. Davies, CTLA-4 and not CD28 is a susceptibility gene for thyroid autoantibody production. The Journal of Clinical Endocrinology and Metabolism. ,vol. 86, pp. 1687- 1693 ,(2001) , 10.1210/JCEM.86.4.7372
Thomas Heiberg Brix, Pia Skov Hansen, Kirsten Ohm Kyvik, Laszlo Hegedus, Aggregation of thyroid autoantibodies in first-degree relatives of patients with autoimmune thyroid disease is mainly due to genes: a twin study. Clinical Endocrinology. ,vol. 60, pp. 329- 334 ,(2004) , 10.1111/J.1365-2265.2004.01983.X
Fotini K. Kavvoura, Takashi Akamizu, Takuya Awata, Yoshiyuki Ban, Dimitry A. Chistiakov, Irena Frydecka, Abbas Ghaderi, Stephen C. Gough, Yuji Hiromatsu, Rafal Ploski, Pei-Wen Wang, Yoshio Ban, Tomasz Bednarczuk, Emma I. Chistiakova, Marcin Chojm, Joanne M. Heward, Hitomi Hiratani, Suh-Hang Hank Juo, Lidia Karabon, Shigehiro Katayama, Susumu Kurihara, Rue-Tsuan Liu, Ikuyo Miyake, Gholam-Hossein R. Omrani, Edyta Pawlak, Matsuo Taniyama, Teruaki Tozaki, John P. A. Ioannidis, Cytotoxic T-Lymphocyte Associated Antigen 4 Gene Polymorphisms and Autoimmune Thyroid Disease: A Meta-Analysis The Journal of Clinical Endocrinology and Metabolism. ,vol. 92, pp. 3162- 3170 ,(2007) , 10.1210/JC.2007-0147
X B Wang, X Zhao, R Giscombe, A K Lefvert, A CTLA-4 gene polymorphism at position -318 in the promoter region affects the expression of protein. Genes and Immunity. ,vol. 3, pp. 233- 234 ,(2002) , 10.1038/SJ.GENE.6363869
Mathias Mäurer, Silke Loserth, Annette Kolb-Mäurer, Anke Ponath, Stefan Wiese, Niels Kruse, Peter Rieckmann, A polymorphism in the human cytotoxic T-lymphocyte antigen 4 ( CTLA4) gene (exon 1 +49) alters T-cell activation. Immunogenetics. ,vol. 54, pp. 1- 8 ,(2002) , 10.1007/S00251-002-0429-9
Eric M. Jacobson, Yaron Tomer, The CD40, CTLA-4, thyroglobulin, TSH receptor, and PTPN22 gene quintet and its contribution to thyroid autoimmunity: Back to the future Journal of Autoimmunity. ,vol. 28, pp. 85- 98 ,(2007) , 10.1016/J.JAUT.2007.02.006