The price of emergency contraception in the United States: what is the cost-effectiveness of ulipristal acetate versus single-dose levonorgestrel?

摘要: Abstract Background Ulipristal acetate (UPA) is a novel form of emergency contraception (EC) that appears to be more effective than the prevailing method, single-dose levonorgestrel (LNG). This study examines cost-efficacy UPA compared with LNG. Study Design A decision-analytic model was developed compare cost-effectiveness versus LNG in preventing unintended pregnancy when taken within 120 h unprotected intercourse. Univariate and bivariate sensitivity analyses, as well Monte Carlo simulation threshold were performed. Results Utilizing instead would result 37,589 fewer pregnancies per 4,176,572 estimated US annual EC uses (UPA 54,295 pregnancies; 91,884 pregnancies) societal savings $116.3 million annually. Cost-effectiveness acceptability curve analyses suggest 96% probability cost-effective at willingness pay $100,000 quality-adjusted life year. Conclusions after Efforts should promoted increase access UPA.