Continuous Positive Airway Pressure Therapy Restores Cardiac Mechanical Function in Patients With Severe Obstructive Sleep Apnea: A Randomized, Sham-Controlled Study.

摘要: Background Continuous positive airway pressure (CPAP) therapy might decrease left ventricular (LV) and right (RV) loads improve cardiac mechanical function in patients with obstructive sleep apnea (OSA). However, the benefits of CPAP for OSA have not previously been proved a randomized, sham-controlled clinical trial. This study therefore investigated effects on LV RV severe compared them sham intervention. Methods In this randomized trial, we analyzed by conventional speckle-tracking echocardiography before after 3 months treatment 52 OSA. Patients were randomly assigned (1:1) to receive either or 3 months. The main investigator masked trial randomization. Results After 3 months, significantly improved global longitudinal strain (GLS) (–20.0% ± 2.1% vs –18.0% ± 2.5%; P = .004), although there no differences dimension ejection fraction. reduced size fractional area change (51.3% ± 7.9% 46.9% ± 6.7%; P = .038) treatment. did ameliorate GLS Conclusions OSA, assessed two-dimensional