Utilizing glutathione-triggered nanoparticles to enhance chemotherapy of lung cancer by reprograming the tumor microenvironment.

摘要: Abstract In the present study, we have developed robust nanoparticles (MGC-GNP/PTX), which are TAMs and tumor cells-dual recognizable, for targeting cancer therapy. Of great importance, nano-platforms glutathione (GSH)-activable, means it remains structure intact under normal physiological condition can be disrupted when exposed to certain concentration of GSH. As demonstrated by drug release assay in vitro, MGC-GNP/PTX exhibited an excellent stability with only 10% cumulative at 72 h. However, after increasing GSH 1 mM or 10 mM, PTX from was significantly accelerated approximately 35% 95% drugs released. Cellular experiments vivo displayed that a super capacity cells TAMs-dual delivery, resulted much stronger cytotoxicity compared unmodified ones. Finally, pharmacodynamic evaluation indicated mice treated strongest suppression ability versus other groups. More importantly, treatment did not influence body weight pathological mice, prepared nanoparticle system had satisfactory bio-safety delivery.