Transgenic mouse model of basal cell carcinoma
作者： Andrzej A. Dlugosz , Chi-Chung Hui
DOI:
关键词: Genetically modified mouse 、 Molecular biology 、 Transgene 、 Cell biology 、 Basal cell carcinoma 、 Biology
摘要: The present invention provides transgenic non-human animal models of basal cell carcinoma which allows for the characterization disease as well providing a system development and testing potential treatments.
lens.org 参考文章(36)
Reiner M. Strojek, Thomas E. Wagner, The Use of Transgenic Animal Techniques for Livestock Improvement Genetic engineering. ,vol. 10, pp. 221- 246 ,(1988) , 10.1007/978-1-4615-7081-3_12
Jun Motoyama, Jason Liu, Rong Mo, Qi Ding, Martin Post, Chi-chung Hui, Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus Nature Genetics. ,vol. 20, pp. 54- 57 ,(1998) , 10.1038/1711
Jingwu Xie, Maximilien Murone, Shiuh-Ming Luoh, Anne Ryan, Qimin Gu, Chaohui Zhang, Jeannette M. Bonifas, Ching-Wan Lam, Mary Hynes, Audrey Goddard, Arnon Rosenthal, Ervin H Epstein, Frederic J. de Sauvage, Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature. ,vol. 391, pp. 90- 92 ,(1998) , 10.1038/34201
Peter G. Zaphiropoulos, Rune Toftgård, Anne Birgitte Undén, Kerstin Bruce, Mona Ståhle-Bäckdahl, Human patched (PTCH) mRNA is overexpressed consistently in tumor cells of both familial and sporadic basal cell carcinoma Cancer Research. ,vol. 57, pp. 2336- 2340 ,(1997)
N. Dahmane, J. Lee, P. Robins, P. Heller, A. Ruiz i Altaba, Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours Nature. ,vol. 389, pp. 876- 881 ,(1997) , 10.1038/39918
Rune Toftgård, Igor Vŏrechovský, Masato Ueda, Keiko Nakazawa, Hiroshi Yamasaki, Hisayoshi Nakazawa, Mireille Kallassy, Patched (ptch)-associated Preferential Expression of Smoothened (smoh) in Human Basal Cell Carcinoma of the Skin Cancer Research. ,vol. 57, pp. 4731- 4735 ,(1997)
Rong Mo, Anne Marie Freer, Dawn L Zinyk, Michael A Crackower, Jacques Michaud, Henry H-Q Heng, Ki Wai Chik, Xiao-Mei Shi, L.-C. Tsui, Shuk Han Cheng, Alexandra L Joyner, C.-C. Hui, Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development. Development. ,vol. 124, pp. 113- 123 ,(1997) , 10.1242/DEV.124.1.113
Janet Rossant, Chi Chung Hui, Stéphan Gasca, Hiroshi Sasaki, Rong Mo, Jun Motoyama, Qi Ding, Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development. ,vol. 125, pp. 2533- 2543 ,(1998) , 10.1242/DEV.125.14.2533
Robert M. Lavker, Stanley Miller, Caroline Wilson, George Cotsarelis, Zhi-Gang Wei, Jing-Shan Yang, Tung-Tien Sun, Hair follicle stem cells: Their location, role in hair cycle, and involvement in skin tumor formation Journal of Investigative Dermatology. ,vol. 101, pp. S16- S26 ,(1993) , 10.1016/0022-202X(93)90496-5
B.R. SMOLLER, M. RIJN, D. LEBRUN, R.A. WARNKE, bcl-2 expression reliably distinguishes trichoepitheliomas from basal cell carcinomas. British Journal of Dermatology. ,vol. 131, pp. 28- 31 ,(1994) , 10.1111/J.1365-2133.1994.TB08453.X