Dehydroepiandrosterone improves psychological well-being in male and female hypopituitary patients on maintenance growth hormone replacement.

摘要: Context: Patients with panhypopituitarism have impaired quality of life (QoL) despite GH replacement. They are profoundly androgen deficient, and dehydroepiandrosterone (DHEA) has been shown to a beneficial effect on well-being mood in patients adrenal failure possibly hypopituitarism. Objective: Our objective was determine the DHEA administration hypopituitary adults established replacement constant serum IGF-I. Design: A double-blind, placebo-controlled trial conducted over an initial 6 months followed by open phase DHEA. Setting: The study at tertiary referral endocrinology unit. Patients: Thirty female 21 male enrolled. Data from 26 females 18 males were analyzed after patient withdrawal. Interventions: (50 mg) added maintenance including GH. Main Outcome Measures: primary outcome QoL libido assessed assessment...