μ-Opioid receptor mRNA expression in the rat CNS : comparison to μ-receptor binding
作者： Alfred Mansour , Charles A. Fox , Robert C. Thompson , Huda Akil , Stanley J. Watson
DOI: 10.1016/0006-8993(94)90031-0
关键词: Interpeduncular nucleus 、 Spinal trigeminal nucleus 、 Biology 、 Dorsal raphe nucleus 、 Cochlear nucleus 、 Inferior colliculus 、 Dorsal motor nucleus 、 Serotonergic cell groups 、 Cell biology 、 Neuroscience 、 Ventral pallidum
摘要: Abstract The distribution of cells expressing μ-receptor mRNA and binding sites were compared in brain spinal cord tissue sections using a combination situ hybridization receptor autoradiographic techniques. μ-Receptor was visualized with 35S-labeled cRNA probe directed to transmembrane III–VI the rat μ-receptor, while labeled μ-selective ligand [3H]DAMGO. A high correspondence between distributions observed nucleus accessory olfactory bulb, anterior nuclei, striatal patches accumbens caudate-putamen, endopiriform nucleus, claustrum, diagonal band Broca, globus pallidus, ventral pallidum, bed stria terminalis, most thalamic medial posteriocortical amygdala, lateral, dorsomedial, posterior mammillary nuclei hypothalamus, presubiculum, subiculum, rostral interpeduncular median raphe, inferior colliculus, parabrachial locus coeruleus, central grey, ambiguus, solitary tract, gracilis, cuneatus, dorsal motor vagus. Differences several regions, including cortex, hippocampus, superior trigeminal cochlear cord, may be due transport presynaptic terminals.
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sci-hub.se 参考文章(63)
H. Khachaturian, Huda Akil, A. Mansour, S. J. Watson, M. E. Lewis, Autoradiographic differentiation of mu, delta, and kappa opioid receptors in the rat forebrain and midbrain The Journal of Neuroscience. ,vol. 7, pp. 2445- 2464 ,(1987)
M Herkenham, CB Pert, Light microscopic localization of brain opiate receptors: a general autoradiographic method which preserves tissue quality The Journal of Neuroscience. ,vol. 2, pp. 1129- 1149 ,(1982) , 10.1523/JNEUROSCI.02-08-01129.1982
I F James, A Goldstein, Site-directed alkylation of multiple opioid receptors. I. Binding selectivity. Molecular Pharmacology. ,vol. 25, pp. 337- 342 ,(1984)
R E Huppler, P E Gilbert, W R Martin, J A Thompson, C G Eades, The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog. Journal of Pharmacology and Experimental Therapeutics. ,vol. 197, pp. 517- 532 ,(1976)
A I Faden, I J Kopin, A Pfeiffer, G Feuerstein, Cardiovascular and respiratory effects of mu-, delta- and kappa-opiate agonists microinjected into the anterior hypothalamic brain area of awake rats. Journal of Pharmacology and Experimental Therapeutics. ,vol. 225, pp. 735- 741 ,(1983)
A Goldstein, A Naidu, Multiple opioid receptors: ligand selectivity profiles and binding site signatures. Molecular Pharmacology. ,vol. 36, pp. 265- 272 ,(1989)
Balraj K. Handa, Anthony C. Lane, John A.H. Lord, Barry A. Morgan, Michael J. Rance, Colin F.C. Smith, Analogues of β-LPH61–64 posessing selective agonist activity at μ-opiate receptors European Journal of Pharmacology. ,vol. 70, pp. 531- 540 ,(1981) , 10.1016/0014-2999(81)90364-2
Gavril W. Pasternak, Pharmacological mechanisms of opioid analgesics. Clinical Neuropharmacology. ,vol. 16, pp. 1- 18 ,(1993) , 10.1097/00002826-199302000-00001
Ellen M. Unterwald, Ann Tempel, George F. Koob, R.Suzanne Zukin, Characterization of opioid receptors in rat nucleus accumbens following mesolimbic dopaminergic lesions. Brain Research. ,vol. 505, pp. 111- 118 ,(1989) , 10.1016/0006-8993(89)90120-0
D. Besse, M.C. Lombard, J.M. Besson, Autoradiographic distribution of μ, δ and κ opioid binding sites in the superficial dorsal horn, over the rostrocaudal axis of the rat spinal cord Brain Research. ,vol. 548, pp. 287- 291 ,(1991) , 10.1016/0006-8993(91)91134-M